The town was established in 1891 on the Onweiler farm north of the present site and was called Hunter. Two years later an I.O.O.F. lodge was organized and called itself Meridian because it was located on the Boise Meridian and the town was renamed. The Settlers' Irrigation Ditch, 1892, changed the arid region into a productive farming community which was incorporated in 1902.

Meridian was incorporated in 1903. The information in the following sections (Irrigation, Village, Rail Transportation, and Creamery) is found on the displays in the Meridian City Hall Plaza.

Early settlers arriving in the area came with no knowledge of gravity flow irrigation. Their previous homes were in areas where rain provided the needed moisture to raise crops. Irrigation soon became a necessity, since having a water source was a requirement for receiving the patent for the land from the U.S. Land Office. Irrigation districts, such as the Nampa-Meridian and Settlers irrigation districts, continue to serve the immediate Meridian area.

The original Meridian town site was filed in 1893 on homestead grant land belonging to Eliza Ann Zenger. Her husband, Christian, filed the plat with county officials and called it Meridian. The early settlers, many of whom were relatives, left their homes in Missouri to go west, either by wagon, train or immigrant railroad car, bringing their lodge and church preferences with them. They established local institutions soon after arriving and filed for homestead lands.

Around the start of the 20th century, settlers established fruit orchards and built fruit packing businesses and prune dryers along the railroad tracks. Local orchards produced many varieties of apples and Italian prunes. Production continued through the mid-1940s, when it was no longer profitable and the businesses closed. In 1941, Meridian's status changed from a village to a city.

Following the raising of $4,000 to lay the Interurban rail line from Onweiler (Meridian and Ustick Roads), the tracks were completed into the village center. Turning east on Broadway and ending at East Second, the last car would spend the night in Meridian before returning to Boise early the next morning with passengers and freight. The interurban Station and Generator building (west one-third of the old library at Meridian and Idaho Streets) was built in 1912, and the line continued on to Nampa via Meridian. The tracks down Broadway were not used after 1912. The Interurban Company entered into receivership and closed in 1928 after 20 years of providing continuous economical transportation to neighboring towns. It was Meridian's main connection to the area outside the local community.

The Union Pacific Railroad spur opened in 1900 and is currently operated by the Boise Valley Railroad. Many industrial customers continue to ship forest, agricultural, and chemical products along this corridor.

The lowest days of the Great Depression brightened for area dairymen when the Ada County Dairymen's cooperative creamery began operation in 1929. It provided milk checks to those who were members of the cooperative, enabling them to pay their taxes and provide food for their families. Other community members hauled milk to the creamery and were employed by the creamery, whose product was Challenge Butter.

The creamery ran 7 days a week for 40 years. Additions and improvements were made while the plant was in full operation. Later years saw the Wyeth Laboratories affiliate with the creamery to manufacture SMA baby formula.

After the creamery ceased local operations in 1970, the dairymen shipped their milk to the Caldwell creamery for processing.

As of the census of 2010, there were 75,092 people, 25,302 households, and 19,916 families living in the city. The population density was 2,803.0 inhabitants per square mile (1,082.2/km²). There were 26,674 housing units at an average density of 995.7 per square mile (384.4/km²). The racial makeup of the city was 92.0% White, 0.8% African American, 0.5% Native American, 1.8% Asian, 0.1% Pacific Islander, 1.9% from other races, and 2.9% from two or more races. Hispanic or Latino of any race were 6.8% of the population.

There were 25,302 households, of which 47.6% had children under the age of 18 living with them, 63.9% were married couples living together, 10.4% had a female householder with no husband present, 4.4% had a male householder with no wife present, and 21.3% were non-families. 16.6% of all households were made up of individuals, and 6% had someone living alone who was 65 years of age or older. The average household size was 2.96 and the average family size was 3.33.

The median age in the city was 32.5 years. 33.4% of residents were under the age of 18; 6.6% were between the ages of 18 and 24; 30.5% were from 25 to 44; 20.7% were from 45 to 64; and 8.9% were 65 years of age or older. The gender makeup of the city was 49.0% male and 51.0% female.

As of the census of 2000, there were 34,919 people, 11,829 households, and 9,515 families living in the city. The population density was 2,962.1/sq mi. There were 12,293 housing units at an average density of 1,042.8 per square mile. The racial makeup of the city was 96.3% White, 0.7% African American, 1% Native American, 2% Asian, 0.3% Pacific Islander, 1.9% from other races, and 2.12% from two or more races. Hispanic or Latino of any race were 3.7% of the population.

There were 11,829 households, out of which 49% had children under the age of 18 living with them, 68.4% were married couples living together, 8.8% had a female householder with no husband present, and 19.6% were non-families. 14.5% of all households were made up of individuals, and 4.3% had someone living alone who was 65 years of age or older. The average household size was 2.93 and the average family size was 3.26.

In the city, the population was spread out, with 33.7% under the age of 18, 6.9% from 18 to 24, 37.1% from 25 to 44, 15.8% from 45 to 64, and 6.4% who were 65 years of age or older. The median age was 30 years. For every 100 females, there were 96.4 males. For every 100 females age 18 and over, there were 93.7 males.

The median income for a household in the city was $53,276, and the median income for a family was $57,077. Males had a median income of $40,360 versus $27,174 for females. The per capita income for the city was $20,150. About 4.6% of families and 5.6% of the population were below the poverty line, including 7.0% of those under age 18 and 7.6% of those age 65 or over.